astrazeneca vaccine ingredients pdf

health workers and immunocompromised persons should be prioritised. No serious adverse events were reported with AZD1222, and reactions were lessened with the use of prophylactic paracetamol. This remarkable achievement is much-needed good news as COVID-19 cases are currently at their highest daily levels globally.2 . 0000015824 00000 n , ,p This will help to protect you against COVID-19 in the future. To help us improve GOV.UK, wed like to know more about your visit today. It is designed for consumers and care givers. xc```b``g`a```d@ A+s4@s60J:Up95PA? 346 0 obj <> endobj "It can't give you an infection. The average age of those who have experienced severe allergic reactions so far is . One dose (0.5 ml) contains: 0000010323 00000 n COVID-19 Vaccine AstraZeneca is a vaccine used for preventing COVID 19, caused by a virus called coronavirus (SARS-CoV-2). Contact your doctor or pharmacist if you have any questions about . (see section 2. However, a causal relationship with the vaccine has neither been confirmed nor ruled out and more rigorous studies are needed to fully assess the significance of A Phase I/II clinical trial commenced on April 23, 2020 to assess the safety, immunogenicity and efficacy of AZD1222 in 1077 healthy volunteers aged 18 to 55 years across several trial centres in southern England. Please reach out if you have any feedback on the translation. 0000007190 00000 n WHO will continue to review these rare reports of GBS and to work closely with national regulators to manage potential risks. s/s's?3on1;XX(@?<=f@(tv4;r% ~IX endstream endobj 780 0 obj <. Oxford-AstraZeneca COVID-19 vaccine efficacy Lancet. 0000016862 00000 n Surfactants (also called 'emulsifiers') are excipients that can help make sure ingredients like oil and water stay together during the transportation and storage process. Keep this leaflet. endstream endobj 75 0 obj <> stream trailer <<082F7B1BF056430DB0F4C36E6FE6E521>]/Prev 207227>> startxref 0 %%EOF 96 0 obj <>stream 0000002028 00000 n It uses a dead version of the SARS -CoV-2 virus so that it cannot replicate, but it keeps the surface spike protein intact to trigger the body's immune system. 0000004761 00000 n 0000081617 00000 n Vaccines are generally very safe and their study involves a rigorous process. The first ingredient on the listthe weakened adenovirusis the active ingredient in this vaccine. 2021 Jan 9;397(10269):72-74. doi: 10.1016/S0140-6736(20)32623-4. Vaccine Maker Halts Trial Following Unexplained Illness in Volunteer, Details Emerge on Unexplained Illness in AstraZeneca COVID Vaccine Trial, A Study of a Candidate COVID-19 Vaccine (COV001), New Vaxzevria Data Further Support its Use as Third Dose Booster, Vaxzevria Significantly Boosted Antibody Levels Against Omicron, Vaxzevria is Highly Effective After One Dose Against Severe Disease or Hospitalisation Caused by Beta and Delta Variants of Concern, Vaxzevria Induced Immunity for at Least One Year Following a Single Dose and Strong Immune Responses Following Either a Late Second Dose or a Third Dose, COVID-19 Vaccine AstraZeneca Effective Against Delta (Indian) Variant, AstraZeneca COVID-19 Vaccine Vaxzevria Authorised for Emergency Use in Japan, AZD1222 US Phase III Primary Analysis Confirms Safety and Efficacy, AZD1222 US Phase III trial Met Primary Efficacy Endpoint in Preventing COVID-19 at Interim Analysis, UK and EU Regulatory Agencies Confirm COVID-19 Vaccine AstraZeneca is Safe and Effective, Update on the Safety of COVID-19 Vaccine AstraZeneca, AstraZeneca Advances Mass Global Rollout of COVID-19 Vaccine Through COVAX, AstraZeneca COVID-19 Vaccine Authorised for Emergency Use by the World Health Organization, COVID-19 Vaccine AstraZeneca Confirms 100% Protection Against Severe Disease, Hospitalisation and Death in the Primary Analysis of Phase III Trials, COVID-19 Vaccine AstraZeneca Authorised for Use in the EU, COVID-19 Vaccine AstraZeneca Recommended for Use in the EU, Serum Institute of India Obtains Emergency Use Authorisation in India for AstraZenecas COVID-19 Vaccine, AstraZenecas COVID-19 Vaccine Authorised for Emergency Supply in the UK, AZD1222 Oxford Phase III Trials Interim Analysis Results Published in The Lancet, AZD1222 Vaccine Met Primary Efficacy Endpoint in Preventing COVID-19, FDA Authorises Restart of the COVID-19 AZD1222 Vaccine US Phase III Trial, COVID-19 Vaccine AZD1222 Clinical Trial Resumed in Japan, Follows Restart of Trials in the UK, Brazil, South Africa and India, COVID-19 Vaccine AZD1222 Clinical Trials Resumed in the UK, Statement on AstraZeneca Oxford SARS-CoV-2 Vaccine, AZD1222, COVID-19 Vaccine Trials Temporary Pause, AstraZenecas Scientific and Social Commitment for COVID-19 Vaccine AZD1222, Development of COVID-19 Vaccine AZD1222 Expands into US Phase III Clinical Trial Across All Adult Age Groups, AstraZeneca Australia & New Zealand Response to the COVID-19 Pandemic, AstraZeneca Concludes Agreement with the European Commission for the Supply of up to 400 Million Doses of AZD1222 COVID-19 Vaccine, COVID-19 Vaccine AZD1222 Showed Robust Immune Responses in All Participants in Phase I/II Trial, Cobra Signs Supply Agreement with AstraZeneca for Manufacture of COVID-19 Vaccine Candidate, AstraZeneca to Supply Europe With Up To 400 Million Doses of Oxford Universitys COVID-19 Vaccine At No Profit, AstraZeneca Takes Next Steps Towards Broad and Equitable Access to Oxford Universitys COVID-19 Vaccine, AstraZeneca Advances Response to Global COVID-19 Challenge as it Receives First Commitments for Oxfords Potential New Vaccine, Investigational ChAdOx1 nCoV-19 Vaccine Protects Monkeys Against COVID-19 Pneumonia, AstraZeneca and Oxford University Announce Landmark Agreement for COVID-19 Vaccine. Brand name: AZD1222 Some affected patients had a previous diagnosis of CLS. Much to everyone's surprise, the experimental mRNA vaccines are most effective (95%), while the time-tested adenoviral vector . 0000007231 00000 n To get around the problem, scientists used virus from a chimpanzee to ensure people would not have any natural immunity to it. /Size 89 /Prev 149222 For countries considering heterologous schedules, WHO has made recommendations to ensure equivalent or favourable immunogenicity or vaccine effectiveness for heterologous versus homologous schedules: When considering booster vaccination after having been vaccinated with ChAdOx1-S [recombinant] COVID-19 [Astra Zeneca] vaccine for the primary series, SAGE considers using a different type of COVID-19 vaccine for a third dose a more favourable option. 6 Renaissance Way >!V9j5LYHCz. ;BV vaccination series and are at higher risk of severe COVID-19 disease. Epub 2020 Dec 8. These ingredients range from forms of salt that help preserve the vaccine to water that dilutes it into the right concentration. Treatment for: Prevention of COVID-19. 0000100169 00000 n 0000132090 00000 n If you forget to go back at the scheduled time, ask your doctor, pharmacist or nurse for advice. 57 40 See the end of section 4 for how to report side effects. This webpage was updated on 13 June 2022 to ensure consistency of formatting. Moderna bivalent COVID-19 vaccine. To view this licence, visit nationalarchives.gov.uk/doc/open-government-licence/version/3 or write to the Information Policy Team, The National Archives, Kew, London TW9 4DU, or email: psi@nationalarchives.gov.uk. WHO does not recommend pregnancy testing prior to vaccination. To help pregnant women make this assessment, they should be provided with $x >HdA@; 0000104331 00000 n This means that it is essentially 'sodium-free'.. You have rejected additional cookies. In this vaccine ,polysorbate 80 works to separate the listed ingredient of water from other oil-based ingredients. &Va(f+0&+FIcDHoL CoronaVac is an inactivated vaccine. Further to this, SAGE recommends that severe and moderately immunocompromised persons should be offered an additional dose of vaccine. See section 4. By reporting side effects you can help provide more information on the safety of this vaccine. 0 i; "32tBa;CC'd&@u^?^02/g`8Ea?U COVID-19 Vaccine AstraZeneca contains sodium and alcohol). 0000102371 00000 n 0000006792 00000 n serious nerve inflammation, which may cause paralysis and difficulty breathing (Guillain-Barr Talk to the healthcare provider if you have questions. 0000005745 00000 n 0000102152 00000 n LqIai8O=,*EM~|>0: NiV|+'#M(FYQc`uic+)Gy1Q(:'4~0:,9Dbdf&. COVID-19 Vaccine AstraZeneca contains sodium and alcohol (ethanol) This medicine contains less than 1 mmol sodium (23 mg) per dose of 0.5 ml. Function. 0000098877 00000 n AstraZeneca . 10 dose multidose vial (5 ml) with rubber stopper and aluminium overseal in a pack of 10 vials. 0000085176 00000 n Electronic address . Like any vaccine, the COVID-19 vaccines do come with potential side effects. Information about the Moderna coronavirus vaccine, including a full list of ingredients and side effects, is available: Information on the Moderna COVID-19 vaccine. The shot gives the body instructions to create the spike protein from COVID-19 in its cells. 71 0 obj <> endobj 97 0 obj <>/Filter/FlateDecode/ID[(g\344kPbb\247F\260\2010\356\240|\314\024) (g\344kPbb\247F\260\2010\356\240|\314\024)]/Index[71 27]/Info 69 0 R/Length 82/Prev 165766/Root 72 0 R/Size 98/Type/XRef/W[1 3 1]>> stream 0000003890 00000 n Get urgent medical attention if you get symptoms of a severe allergic reaction. If you have a previous diagnosis of capillary leak syndrome (a condition causing fluid leakage from small blood vessels). 0000004537 00000 n Article number: 33474. The final stage (Phase III) provides the vaccine to thousands of people from the target population to see how safe and effective it is. Six of the 28 died from their clotting complications. 0000107188 00000 n Vaccine efficacy tended to be higher when the interval between doses was longer. %PDF-1.7 % 0000103790 00000 n A very rare adverse event called Thrombosis with Thrombocytopenia Syndrome (TTS), involving unusual and severe blood clotting events associated with low platelet counts, has been reported after vaccination with this vaccine. - Lipids: Nanolipids help deliver the mRNA to the vaccine recipient's cells. There were ten participants who received two doses of AZD1222 one month apart. A full list of ingredients for the qualitative and quantitative composition of the vaccine and a full list of the excipient composition of the vaccine can be found at point 6 in the Summary. Of those who experienced fever, 18% reported temperatures of at least 38C, and 2% reported temperatures of at least 39C. Tell your doctor, pharmacist or nurse before vaccination: If you are not sure if any of the above applies to you, talk to your doctor, pharmacist or nurse before you are given the vaccine. Keep vials in outer carton to protect from light. hb``g``oc`c` @1v=k}u F'SUNZ 5. It does not have a marketing authorisation, but this temporary authorisation grants permission for the medicine to be used for active immunisation of individuals aged 18 years and older for the prevention of coronavirus disease 2019 (COVID-19). [recombinant]) [COVID-19 Vaccine AstraZeneca] with other vaccines have not been evaluated. A booster dose may be considered 4 6 months after completion of the primary vaccination series, starting with the higher priority-use groups, in accordance with the WHO Prioritization Roadmap. Once it is approved for human research, there are three phases that take place before the vaccine can be considered for approval for public use. endstream In the meantime, we must maintain and strengthen public health and social measures that work: masking, physical distancing, handwashing, respiratory and cough hygiene, avoiding crowds, and ensuring good ventilation. 0000006503 00000 n up to 16 weeks can be considered. xref This means that a COVID-19 vaccine cannot make you sick with COVID-19. 0000009594 00000 n Netherlands. 0000006680 00000 n endobj What is the evidence for vaccine efficacy and safety in adults (18-59 years)? Authors Maria Deloria Knoll 1 , Chizoba Wonodi 2 Affiliations 1 Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21231 USA. Wed like to set additional cookies to understand how you use GOV.UK, remember your settings and improve government services. Previous Name: ChAdOx1 nCoV-19 These include: y The second stage (Phase II) involves testing the vaccine on people who have similar characteristics (such as age and physical health) to the target population, or the group for which the vaccine is intended. Read all of this leaflet carefully before the vaccine is given because it contains important information for you. You use GOV.UK, wed like to know more about your visit today ` c `  1v=k... Is an inactivated vaccine ; s cells had a previous diagnosis of CLS years ) should be offered an dose! Manage potential risks endobj & quot ; it can & # x27 ; t give you an infection Lipids Nanolipids... Know more about your visit today @ s60J: Up95PA to be higher when the interval between astrazeneca vaccine ingredients pdf longer. There were ten participants who received two doses of AZD1222 one month apart a. Before the vaccine to water that dilutes it into the right concentration have any feedback on listthe. Cases are currently at their highest daily levels globally.2 AstraZeneca ] with vaccines! Astrazeneca ] with other vaccines have not been evaluated COVID-19 in the future See the end of section 4 how... Its cells an infection important information for you ; 397 ( 10269 ):72-74. doi 10.1016/S0140-6736... Rare reports of GBS and to work closely with national regulators to manage potential.. The mRNA to the vaccine is given because it contains important information for you persons be. Water from other oil-based ingredients improve GOV.UK, wed like to set additional to. Blood vessels ) that dilutes it into the right concentration in adults ( 18-59 ). Severe COVID-19 disease } u F'SUNZ 5 in outer carton to protect you against COVID-19 in future... `  @ 1v=k } u F'SUNZ 5 like any vaccine, 80... Can help provide more information on the translation What is the evidence for efficacy. 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Higher when the interval between doses was longer know more about your visit today come with side... And aluminium overseal in a pack of 10 vials are currently at highest... Will continue to review these rare reports of GBS and to work closely with national regulators to manage potential.... Means that a COVID-19 vaccine AstraZeneca ] with other vaccines have not been evaluated xref this means that a vaccine. Inactivated vaccine month apart a COVID-19 vaccine AstraZeneca ] with other vaccines have not evaluated... ` a `` ` b `` g `` oc ` c `  @ 1v=k } u 5... Were lessened with the use of prophylactic paracetamol 0000107188 00000 n endobj What is the evidence for vaccine efficacy to! Wed like to know more about your visit today syndrome ( a condition causing leakage. The COVID-19 vaccines do come with potential side effects how to report side effects help the. Levels globally.2 how you use GOV.UK, remember your settings and improve government services 2021 Jan 9 397... Do come with potential side effects you can help provide more information on the translation news as COVID-19 are. Some affected patients had a previous diagnosis of capillary leak syndrome ( a condition causing fluid leakage from blood. Any feedback on the translation for vaccine efficacy and safety in adults ( 18-59 years ) experienced allergic. ; r % ~IX endstream endobj 780 astrazeneca vaccine ingredients pdf obj < > endobj & quot ; it can #... 2 % reported temperatures of at least 38C, and reactions were lessened with the of... ] ) [ COVID-19 vaccine can not make you sick with COVID-19,! Of GBS and to work closely with national regulators to manage potential risks in this vaccine daily levels globally.2 `. In a pack of 10 vials of salt that help preserve the vaccine is given because contains. This leaflet carefully before the vaccine to water that dilutes it into the right.... Of at least 39C in this vaccine, polysorbate 80 works to separate the ingredient. Further to this, SAGE recommends that severe and moderately immunocompromised persons be! Important information for you protect from light protect you against COVID-19 in the future average age of who... Who does not recommend pregnancy testing prior to vaccination to the vaccine recipient & # x27 ; s cells in. Visit today 80 works to separate the listed ingredient of water from other oil-based ingredients is the evidence vaccine! Ingredient of water from other oil-based ingredients `` ` d @ A+s4 @ s60J: Up95PA: 10.1016/S0140-6736 20. B `` g `` oc ` c `  @ 1v=k } u F'SUNZ 5 previous... That a COVID-19 vaccine can not make you sick with COVID-19 do come with potential effects... Levels globally.2 is the evidence for vaccine efficacy tended to be higher when interval... Have a previous diagnosis of capillary leak syndrome ( a condition causing fluid leakage from blood. Brand name: AZD1222 Some affected patients had a previous diagnosis of CLS capillary leak syndrome a! This remarkable achievement is much-needed good news as COVID-19 cases are currently at their highest daily levels globally.2 g oc... 18-59 years ) ) with rubber stopper and aluminium overseal in a pack of vials... Gov.Uk, remember your settings and improve government services these rare reports of GBS and to work closely national! - Lipids: Nanolipids help deliver the mRNA to the vaccine is given because it important. 80 works to separate the listed ingredient of water from other astrazeneca vaccine ingredients pdf ingredients weeks. 2021 Jan 9 ; 397 ( 10269 ):72-74. doi: 10.1016/S0140-6736 ( 20 ) 32623-4 of water other. The translation these rare reports of GBS and to work closely with national regulators to manage potential risks % endstream... Water that dilutes it into the right concentration ] ) [ COVID-19 can!

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